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Research Only
Triple Receptor Agonist

Retatrutide

Research Peptide

A novel 39-amino acid peptide targeting GLP-1, GIP, and glucagon receptors. Currently in Phase 3 clinical trials by Eli Lilly.

99%+
Purity
6 Day
Half-Life
3
Receptors
Retatrutide research peptide vial
99%+ Pure
LY3437943
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Triple Agonist Mechanism

Mechanism of Action

Retatrutide simultaneously activates three incretin hormone receptors, creating a synergistic effect studied in metabolic research applications.

GIP Receptor

GIPR
Relative Potency0.0643 nM

Highest affinity binding - glucose-dependent insulin secretion and lipid metabolism

GLP-1 Receptor

GLP-1R
Relative Potency0.775 nM

Satiety signaling, gastric emptying modulation, glycemic control

Glucagon Receptor

GCGR
Relative Potency5.79 nM

Hepatic glucose regulation, thermogenesis, lipid mobilization

EC50 values represent the concentration required for 50% maximal response. Lower values indicate higher binding affinity. Data sourced from published research literature.

Clinical Research Data

Research Highlights

Key findings from published Phase 2 clinical trials and peer-reviewed research.

24.2%

Mean Weight Reduction

At 48 weeks with 12mg dose

NEJM Phase 2 Trial
82.4%

Liver Fat Reduction

At 24 weeks with 12mg dose

Nature Medicine
100%

Achieved 5%+ Weight Loss

All participants in 12mg cohort

PMC Meta-Analysis
83%

Achieved 15%+ Weight Loss

Phase 2 48-week results

Eli Lilly Press Release

Published Research Citations

Data presented is derived from peer-reviewed publications including the New England Journal of Medicine, Nature Medicine, and PubMed Central. Research outcomes are for informational purposes only and pertain to clinical trial contexts. This compound is sold strictly for laboratory research purposes.

Compound Profile

Molecular Profile

Retatrutide (LY3437943) is a weekly single-agent peptide featuring strategic amino acid modifications for enhanced stability and receptor selectivity.

Peptide Length39 amino acids
Fatty Acid MoietyC20 fatty diacid
Half-Life~6 days
Dosing FrequencyOnce weekly
Molecular Weight~4,500 Da
ModificationsAib2, Aib20, αMeL13
Retatrutide molecular structure showing 39 amino acid peptide chain with C20 fatty diacid and Aib2, Aib20, α-MeLeu modifications
Research Products

Available for Research

High-purity Retatrutide peptide for qualified research applications. Third-party tested and verified.

View 10mg Product

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99%+ Purity
HPLC Verified
Third-Party Tested
Independent Labs
Fast Shipping
USA Based
Fresh Stock
Made to Order
Quality Assurance

Certificate of Analysis

Every batch is third-party tested for purity and identity. View our HPLC test results confirming 99%+ purity.

RT 10MG - COA

HPLC Purity Analysis

RT 20MG - COA

HPLC Purity Analysis

Certificates of Analysis are included with every order. Additional testing documentation available upon request.

FOR RESEARCH PURPOSES ONLY

This product is intended strictly for laboratory and scientific research purposes. It is not intended for human or animal consumption, therapeutic use, or any other non-research application.

Retatrutide (LY3437943) is an investigational compound currently undergoing clinical trials. It has not been approved by the FDA or any other regulatory agency for medical use.

By purchasing this product, you confirm that you are at least 21 years of age, are purchasing for legitimate research purposes, and agree to our Terms & Conditions.

No Medical Claims

Premier Research makes no claims regarding the safety, efficacy, or therapeutic benefits of this compound. All research data presented is sourced from published clinical literature and is for informational purposes only.

Qualified Researchers

This product is sold exclusively to qualified researchers and institutions. Purchasers must have appropriate knowledge and facilities for handling research chemicals safely and responsibly.

Ready to Begin Your Research?

High-purity Retatrutide peptide available for qualified research applications. Order today for fast USA shipping.